Led by the International One Health Platform (that closed its doors in 2021), this congress built upon the excellent sessions and debates at previous International One Health Congresses organized in Melbourne (2011, 2013,) Bangkok and Amsterdam (2015) to give the floor to the most renowned experts and researchers. Since the first congress in 2011, the One Health approach has been increasingly accepted by major international health oriented organizations, academic research institutes, field workers and the pharmaceutical industry. The growing movement of One Health advocates who strongly support the idea of an integrated approach to human, animal and environmental health as the best solution to complex and urgent health threats were warmly welcomed.