Health experts from around the world met for a symposium focused on the current and potential movements of diseases among human, domestic animal, and wildlife populations. Using case studies on Ebola, Avian Influenza, and Chronic Wasting Disease as examples, the assembled expert panelists delineated priorities for an international, interdisciplinary approach for combating threats to the health of life on Earth. The product – called "The Manhattan Principles" lists 12 recommendations for establishing a more holistic approach to preventing epidemic/epizootic disease and for maintaining ecosystem integrity for the benefit of humans, their domesticated animals, and the foundational biodiversity that supports us all.