With the 21st Century came a nagging awareness: 1) untoward side effects of human progress are threatening the health of our planet and all Life that it supports; and 2) we have lost an ancient holistic wisdom of the interconnectedness of all Life. A global call arose to reconnect our wells of knowledge to jointly address our global challenges, and the concept now known as One Health slowly began to take root. It has become a movement that is viewed by many as a ‘ray of hope’ for the future.